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KMID : 1098420080160020100
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 2 p.100 ~ p.105
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Scutellaria baicalensis Modulates Cytokine Production, T Cell Population and Immunoglobulin Level by Mesenteric Lymph Node Lymphocytes in Experimental Mice with Colitis
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Lim Byong-Ou
Choi Wahn-Soo
Park Pyo-Jam
Kim Jong-Dai
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Abstract
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We previously examined extracts, isolated from Scutellaria baicalensis (SB), chemical mediators, and IgE by mesenteric lymph node (MLN) lymphocytes in rats. The present study was to evaluate the effects of extracts of SB on the MLN lymphocytes function of mice given orally by 20 mg/kg for 2 weeks with dextran sulfate sodium (DS)-induced colitis. Results show that IgE levels in MLN lymphocytes was low, while IgA was high, in mice given SB compared to that fed water. Concentrations of and interleukin (IL)-2 of T cells by concanavalin A treatment was significantly higher in the SB fed group than the normal group. Activation-induced IL-4 and IL-10 secretion was lower in SB fed mice compared control mice after DS-induced colitis. These results suggested that SB suppresses the inflammation in DS-induced colitis through the modulation of Th1/Th2 balance to down-regulate response in MLN lymphocytes.
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KEYWORD
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Scutellaria baicalensis, IgE and IgA, Inflammatory Bowel Disease, Mesenteric Lymph Node
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